EVALUATION OF AIRBORNE EXPOSURE-LIMITS FOR G-AGENTS:

1,34

MB

OCCUPATIONAL AND GENERAL POPULATION EXPOSURE CRITERIA

90

stron

2312

ID

U.S. Army Edgewood Chemical Biological Center

1999

rok

CONTENTS

1. PURPOSE

2.1 Introduction

2.2 Chemical and Physical Properties

2.3 Biological Properties

2.3.1 Mechanism of Action

2.3.2 G-agent Vapor Intoxication: Local vs. Systemic Responses

2.3.3 Assessing the Severity of G-agent Intoxication.

2.3.4 Acute Toxic Effects of G-agents by Inhalation Exposure.

2.3.5 Central Nervous System (CNS) Effects

2.3.6 Delayed Neuropathy

2.3.7 Cardiac Complications

2.3.8 Mutagenicity, Carcinogenicity, Teratogenicity and Reproductive Toxicity

3. FINDINGS/DISCUSSION

3.1 Human Exposure Data

3.2 Developing Exposure Criteria: a Traditional Approach

3.3 Selecting the ‘Critical Adverse Effect(s)” for G-Agent Airborne Exposure Criteria

3.4 Derivation of Airborne Exposure bvels for GB: Considerations in Selecting a Critical Study

3.4.1 Calculating the AEL for Occupational Workers (Worker Population Limit or WPL) for GB Vapor

3.4.2 Calculating the AEL for General Population (General Population Limit or GPL) for GB Vapor

3.4.3 Summary of Airborne Exposure Levels for GB Vapor

3.5 Derivation of Airborne Exposure Levels for GA, GD, and GF

4. CONCLUSIONS

5. RECOMMENDATIONS

LITERATURE CITED

GLOSSARY