| | Public Health Goal for Methyl Tertiary Butyl Ether (MTBE) in |
| | 0,39 | | MB | Drinking Water |
| | 120 | | stron |
| | 2474 | | ID | California Environmental Protection Agency |
| | 1998 | | rok |
| | TABLE OF CONTENTS |
| | LIST OF CONTRIBUTORS. ii |
| | PREFACE.iii |
| | LIST OF ABBREVIATIONS v |
| | TABLE OF CONTENTS x |
| | SUMMARY 1 |
| | INTRODUCTION 1 |
| | CHEMICAL PROFILE .. 4 |
| | CHEMICAL IDENTITY . 4 |
| | PHYSICAL AND CHEMICAL PROPERTIES . 5 |
| | ORGANOLEPTIC PROPERTIES 5 |
| | PRODUCTION AND USES 10 |
| | ENVIRONMENTAL OCCURRENCE AND HUMAN EXPOSURE.. 11 |
| | AIR, SOIL, FOOD, AND OTHER SOURCES 12 |
| | WATER 13 |
| | METABOLISM AND PHARMACOKINETICS.. 16 |
| | ABSORPTION .. 17 |
| | DISTRIBUTION .. 17 |
| | METABOLISM. 17 |
| | EXCRETION . 18 |
| | PHARMACOKINETICS .. 19 |
| | PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODELS 20 |
| | TOXICOLOGY.. 20 |
| | TOXICOLOGICAL EFFECTS IN ANIMALS 21 |
| | Acute Toxicity .. 27 |
| | Subacute Toxicity 28 |
| | Subchronic Toxicity 28 |
| | Genetic Toxicity .. 29 |
| | Developmental and Reproductive Toxicity .. 30 |
| | Immunotoxicity. 44 |
| | Neurotoxicity . 45 |
| | Chronic Toxicity.. 45 |
| | Carcinogenicity. 46 |
| | Ecotoxicity.. 57 |
| | TOXICOLOGICAL EFFECTS IN HUMANS. 58 |
| | Acute Toxicity .. 58 |
| | Immunotoxicity. 62 |
| | Neurotoxicity . 62 |
| | DOSE-RESPONSE ASSESSMENT.. 63 |
| | INTERNAL DOSE ESTIMATION.. 63 |
| | NONCARCINOGENIC EFFECTS.. 68 |
| | CARCINOGENIC EFFECTS . 68 |
| | Possible Modes of Action . 68 |
| | Estimation of Carcinogenic Potency 68 |
| | CALCULATION OF PHG . 74 |
| | NONCARCINOGENIC EFFECTS.. 74 |
| | EXPOSURE FACTORS 75 |
| | CARCINOGENIC EFFECTS . 79 |
| | RISK CHARACTERIZATION. 80 |
| | ACUTE HEALTH EFFECTS . 80 |
| | CARCINOGENIC EFFECTS . 80 |
| | OTHER REGULATORY STANDARDS. 83 |
| | REFERENCES. 86 |