Environmental and Occupational Causes of Cancer - A Review of

2,41
MB Recent Scientific Literature

50
stron

3555
ID Lowell Center for Sustainable Production

2005
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TABLE OF CONTENTS

EXECUTIVE SUMMARY.1

INTRODUCTION 3

ESTIMATING ENVIRONMENTAL AND OCCUPATIONAL CONTRIBUTIONS TO CANCER 4

A Look at Recent History .4

Causes: Genes or Environment? .6

PERSPECTIVES ON RESEARCH METHODS.7

Epidemiologic and Animal Studies: Strengths and Limitations.7

Cancer Clusters.7

Cancer Incidence and Mortality Data .8

THE STATE OF THE SCIENCE9

Methodology .9

The State of the Science by Cancer Type.12

Bladder Cancer.12

Bone Cancer .12

Brain and other Central Nervous System Cancers12

Breast Cancer .13

Cervical Cancer 14

Colon Cancer .15

Esophageal Cancer 15

Hodgkin’s Disease.15

Kidney Cancer16

Laryngeal Cancer .16

Leukemia.17

Liver and Biliary Cancer .17

Lung Cancer .18

Mesothelioma.19

Multiple Myeloma20

Nasal and Nasopharynx .20

Non-Hodgkin’s Lymphoma 20

Ovarian Cancer 21

Pancreatic Cancer 21

Prostate Cancer22

Rectal Cancer .22

Soft Tissue Sarcomas (STS) .23

Skin Cancer.23

Stomach Cancer.23

Testicular Cancer .24

Thyroid Cancer 24

COMMENTS AND DISCUSSION .25

RECOMMENDATIONS.29

REFERENCES.30

APPENDICES37

Appendix 1. Substances and mixtures that have been evaluated by IARC as definite (group 1)

human carcinogens and that are occupational exposures 37

Appendix 2. Occupations or industries evaluated by IARC as definitely, probably, or possibly

entailing excess risk of cancer among workers. 39

Appendix 3. Definite or probable occupational carcinogens and carcinogenic circumstances, by site.

40

Appendix 4. Mortality rates from cancer and heart disease for ages younger than 85 and 85 and

older, 1975-2001. .41

Appendix 5. Incidence rates for all cancer sites by race and sex for ages 64 and under, 1973-

200142

Appendix 6. Incidence rates for all cancer sites by race and sex for ages 65 and over, 1973-200143



Appendix 7. Mortality rates for all cancer sites by race and sex for ages 64 and under, 1969-

2001.44

Appendix 8. Mortality rates for all cancer sites by race and sex for ages 65 and over, 1969-2001.45



Appendix 9. Incidence rates for lung & bronchus cancers by race and sex, 1973-2001. .46