EVALUATION OF LEUKEMIA, LIVER CANCER, AND LUNG CANCER IN

1,51

MB

MARLBOROUGH, MASSACHUSETTS: 1982-2002

95

stron

3586

ID

Massachusetts Department of Public Health

2006

rok

I. INTRODUCTION 1

II. BACKGROUND AND STATEMENT OF ISSUES. 1

III. OBJECTIVES 2

IV. METHODS FOR ANALYZING CANCER INCIDENCE DATA.. 3

A. CASE IDENTIFICATION/DEFINITION 3

B. CALCULATION OF STANDARDIZED INCIDENCE RATIOS (SIRS).4

C. INTERPRETATION OF STANDARDIZED INCIDENCE RATIO (SIR) 4

D. CALCULATION OF THE 95% CONFIDENCE INTERVAL.5

E. EVALUATION OF RISK FACTOR INFORMATION .6

F. GEOGRAPHIC DISTRIBUTION .6

G. CANCER INCIDENCE IN THE GLEN STREET NEIGHBORHOOD..7

V. RESULTS OF CANCER INCIDENCE ANALYSES. 7

A. LEUKEMIA.8

1. Leukemia Incidence in Marlborough, MA.8

2. Leukemia Incidence in Marlborough Census Tracts 8

B. LIVER CANCER9

1. Liver Cancer Incidence in Marlborough, MA .9

2. Liver Cancer Incidence in Marlborough Census Tracts .10

C. LUNG CANCER .10

1. Lung Cancer Incidence in Marlborough, MA10

2. Lung Cancer Incidence in Marlborough Census Tracts..11

VI. EVALUATION OF RISK FACTOR INFORMATION. 12

A. LEUKEMIA..12

1. Histology (Cell Type).13

2. Gender/Age Distribution .13

3. Temporal Distribution ..14

4. Occupation 15

5. Other Risk Factors.16

6. Residential History .16

B. LIVER CANCER.17

1. Gender/Age Distribution .17

2. Personal Risk Factors ..18

3. Occupation 18

C. LUNG CANCER .19

1. Gender/Age Distribution .19

2. Smoking Status.20

3. Occupation 21

VII. GEOGRAPHIC DISTRIBUTION .. 21

A. LEUKEMIA..22

B. LIVER CANCER.23

C. LUNG CANCER .23

VIII. CANCER INCIDENCE IN THE GLEN STREET NEIGHBORHOOD. 24

IX. COMMUNITY ENVIRONMENTAL CONCERNS. 25

X. DISCUSSION.. 26

XI. LIMITATIONS.. 27

XII. CONCLUSIONS . 27

XIII. RECOMMENDATIONS 28

XIV. REFERENCES 30