Evaluation of Certain Veterinary Drug in Food

0,52

MB

109

stron

3682

ID

World Health Organization

2006

rok

Contents

1. Introduction 1

2. General considerations 1

2.1 The formulation of advice on compounds that are both genotoxic and carcinogenic 2

2.2 Establishing an acute reference dose 6

2.3 Short-term dietary intakes of contaminants 7

2.4 Data on levels of contaminants in food and the total diet 7

3. The toxicological evaluation of compounds on the agenda 8

3.1 Acrylamide 8

3.2 Cadmium — impact assessment of different maximum limits 26

3.3 Ethyl carbamate 31

3.4 Inorganic tin 40

3.5 Polybrominated diphenyl ethers 44

3.6 Polycyclic aromatic hydrocarbons 61

4. Future work 79

5. Recommendations 80

Acknowledgements 81

References 81

Annex 1

Reports and other documents resulting from previous meetings of the Joint FAO/WHO Expert

Committee on Food Additives 84

Annex 2

Summary of toxicological evaluations 93

Annex 3

Approach to dose–response modelling 97

Corrigendum 100