ENVIRONMENTAL HEALTH CRITERIA FOR BIOMARKERS IN RISK

1,19

MB

ASSESSMENT: VALIDITY AND VALIDATION

136

stron

3683

ID

World Health Organization

2006

rok

CONTENTS

PREAMBLE

ABBREVIATIONS

1. INTRODUCTION

2. RISK ASSESSMENT

2.1 Hazard identification

2.2 Dose response

2.3 Exposure assessment for risk assessment

3. VALIDITY AND VALIDATION - GENERAL CONSIDERATIONS

4. VALIDATION OF SPECIFIC TYPES OF BIOMARKERS

4.1 Exposure biomarkers

4.2 Effect biomarkers

4.3 Susceptibility biomarkers

5. CROSS-SPECIES COMPARABILITY

6. NEW PERSPECTIVES

7. SUMMARY

8. CONCLUSIONS

9. RECOMMENDATIONS

9.1 General recommendations

9.2 Recommendations for future research

9.2.1 Prevalidation stage

9.2.2 Validation stage

9.3 Application

REFERENCES

APPENDIX I. BIOMARKERS OF EXPOSURE AND EFFECT FOR CARCINOGENICITY

APPENDIX II. BIOMARKERS OF EXPOSURE AND EFFECT FOR NON-CARCINOGENIC END-

POINTS

APPENDIX III. MEASUREMENT OF DRUG METABOLIZING ENZYME POLYMORPHISMS AS

INDICATORS OF SUSCEPTIBILITY

APPENDIX IV. VALIDATION OF BIOMARKERS FOR ENVIRONMENTAL HEALTH RESEARCH

AND RISK ASSESSMENT

RESUME