Chemical Warfare Agents: Estimating Oral Reference Doses

6,45
MB

183
stron

3868
ID Oak Ridge National Laboratory

2006
rok

Contents

I. Introduction

A. Objectives

B. Approach

C. Chemical Agents of Concern .

D. Review Process .

II. Physical and Chemical Properties

A. Mustard Agents

B. Nerve Agents

C. Agent L

D. Agent CK (Cyanogen Chloride)

III. Signs, Symptoms, and Mechanisms of Toxicity .

A. Mustard Agents

B. Nerve Agents .

C. Agent L (Lewisite) . .

D. Azent CK (Cyanogen Chloride)

IV. Methodology for Deriving Oral Reference Doses .

V. Agent HD (Sulfur Mustard) .

A. Toxicology

B. Estimated Reference Dose

VI. Agent HT (Sulfur Mustard)

A. Toxicology

B. Estimated Reference Dose .

Communicated by George W. Ware

VII . Agent T

A . Toxicology .

B . Estimated Reference Dose .

VIII . Agent HN2 (Nitrogen Mustard) .

A . Toxicoloey .

B . Estimated Reference Dose

IX . Agent VX .

A . Toxicology .

B . Estimated Reference Dose .

X . Agent GA (Tabun)

A . Toxicology

B . Estimated Reference Dose

XI . Agent GB (Sarin)

A . Toxicology .

B . Estimated Reference Dose

XII . Agent GD (Soman)

A . Tosicology .

B . Estimated Reference Dose .

XIII . Agent L (Lewisite) .

A . Toxicology .

B . Estimated Reference Dose .

XIV . Agent CK (Cyanogen Chloride) .

A . Toxicology .

B . Estimated Reference Dose . .

XV . Environmental Fate and Effects .

A . Mustard Agents

B . Nerve Agents

C . Agent L (Lewisite) .

D . Agent CK (Cyanogen Chloride)

XVI . Discussion and Conclusions

Summary

Appendix A: List of Acronyms and Abbreviations .

Appendix B: Glossary of Technical Terms

References