Labelling techniques of biomolecules for targeted radiotherapy

1,76
MB

196
stron

4693
ID International Atomic Energy Agency

2003
rok

CONTENTS

INTRODUCTION. 1

ACHIEVEMENTS OF THE CRP . 2

SCOPE OF THE CRP AND TECHNICAL OBSERVATIONS . 3

REMARKS ON METHODOLOGIES FOR RADIOLABELLING AND QUALITY CONTROL OF

SELECTED BIOMOLECULES . 14

POTENTIAL AREAS OF FUTURE RESEARCH . 16

COLLABORATIVE ACTIVITIES . 17

TECHNICAL CONCLUSIONS OF THE CRP. 17

PUBLICATIONS AND PRESENTATIONS ORIGINATING FROM THE CRP . 18

BIBLIOGRAPHY. 25

COUNTRY REPORTS

Optimization of biomolecules labelling with Rhenium-188

using direct and indirect methods. 31

S.G. de Castiglia, J. Crudo, E. Obenaus, M. Edreira, E. D’orio

Labelling of peptides with 188Re/99Tcm and monoclonal antibodies with 90Y/111In . 45

B. Linkowski Faintuch, C.P.G. Silva, N.P.S. Pereira, E.B. Araujo

Labelling technique of biomolecules for target radiotherapy 65

Hongsheng Bai, Jin Xiaohai, Cheng Zhen, Jia Bing Fan Hongqiang, Lu Weiwei

Evaluation of biomolecules for metabolic radiotherapy 73

G.J. Pimentel, M. Miranda, W. Quesada, H.E. Garay, O. Reyes, J. Vazquez, L.J. Cruz, I. Sanchez

Development of radioactively labelled cancer seeking biomolecules for targeted therapy 85

A.D. Varvarigou, S.C. Archimandritis, M. Fani, P. Bouziotis, S. Vranjez, S. Xanthopoulos, A. Leonti,

Th. Sourlingas, M. Sotiropoulou

Preparation, quality control and animal testing of Re-188 labelled compounds . 99

G.A. Jánoki, L. Körösi, L. Balogh, G. Andócs, K. Bodó, J. Láng, A. Polyák, R. Király, Domokos

Development of radioactively labelled cancer seeking biomolecules for targeted therapy. 107

M.R.I. Pillai, M. Venkatesh, S. Banerjee, G. Samuel, K. Kothari, A. Dash, P.R. Unni, A. Korde, K.

Bapat, U. Pandey, T. Dash, S. Chakraborty, A. Mukherjee, H.D. Sharma

Labelled peptides through the DOTA chelating agent for diagnosis and treatment of receptor positive

tumours . 123

M. Chinol

Labelled biomolecules for targeted radiotherapy: Biodistribution in mice with induced malignant

tumours 129

C. Arteaga de Murphy, G. Ferro-Flores, M. Pedraza-López, E.M. Molina-Trinidad, E. Murphy-Stack,

S. Hernández-Gutiérrez

Labelled biomolecules with 153Sm, 188Re, and 90Y for targeted radiotherapy 139

A. Mushtaq, S. Perverz, M. Khalid

Development of 188Re radiolabelling procedures of peptides and monoclonal antibodies 155

V.V. Lungu, G. Mihailescu, D. Niculae

Radiolabelling of monoclonal antibodies for radiotherapy 165

J. Sangsuriyan, C. Wardwilai, W. Iamsam-Ang, T. Ngamprayad, P. Picha, M. Dangpraset

Labelling and control of biomolecules with 188Re and 153Sm 183

H.S. Balter, E.S. Verdera, G. Rodríguez, P. Oliver, B. Souto, L. Mallo, A. Robles

LIST OF PARTICIPANTS 197